Workshop: The role of antioxidants in thalassaemia.
ESCP European Symposium Clinical Pharmacy, Dubrovnik, Croatia, 22-24 October 2008: Pharmaceutical Care Models & Therapeutic Innovations. ESCP News, Issue No 140, August 2008.
Thalassaemia is a complex condition that is characterized by the absence or reduction in the production of haemoglobin. While oxidant production is markedly elevated, as indicated by increased lipid peroxidation product, malondialdehyde (MOA), endogenous antioxidants are depleted in thalassaemia. The level of antioxidants such as glutathione is markedly decreased while activities of antioxidant enzymes including catalase and glutathione peroxidase are increased. Natural or synthetic antioxidants can alleviate the oxidative stress in thalassemic patients The workshop will review the use of dietary supplements and dietary action plans for thalassemic patients.